PG | 2h 28m
When a failed nuclear fusion experiment results in an explosion that kills his wife, Dr. Otto Octavius (Alfred Molina) is transformed into Dr. Octopus, a cyborg with deadly metal tentacles. Doc Ock blames Spider-Man (Tobey Maguire) for the accident and seeks revenge. Meanwhile, Spidey's alter ego, Peter Parker, faces fading powers and self-doubt. Complicating matters are his best friend's (James Franco) hatred for Spider-Man and his true love's (Kirsten Dunst) sudden engagement to another man.
Rosemary Harris, Donna Murphy, J.K. Simmons, Kirsten Dunst, Vanessa Ferlito, Alfred Molina, Tobey Maguire, Ted Raimi, Cliff Robertson, Elizabeth Banks, Daniel Gillies, Willem Dafoe, Michael Edward Thomas, Bill Nunn, Gregg Edelman, Bruce Campbell, Elya Baskin, Aasif Mandvi, James Franco, Dylan Baker
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