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U.S. fertility clinic promises 'designer babies'

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Canada AM: Dr. Mark Hughes, molecular geneticist

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CTV.ca News Staff

Date: Tue. Mar. 3 2009 9:18 AM ET

A U.S. fertility clinic is courting controversy that it is wading into the realm of "designer babies" after announcing recently that it can help expectant parents choose the genetic traits of their future children.

Fertility Institutes says it will soon offer a service to help couples select both their baby's gender and physical traits, such as eye or hair colour, using pre-implantation genetic diagnosis, or PGD.

The clinic says it has already received "half a dozen" requests for the service, which will be available to couples undergoing IVF, or in vitro fertilization.

The clinic claims it can make no guarantees as to "perfect prediction" of things such as eye or hair colour. But it has already been using PGD for gender selection and claims it has a success rate in that area of greater than 99 per cent.

PGD is already used at fertility clinics around the world for couples who have recurrent miscarriages, or who need to screen out embryos that have inherited the genes for life-threatening diseases.

In Canada, its use for gender selection is illegal under the Assisted Human Reproduction Act. That's not the case in the U.S. which has looser regulations on fertility clinics.

In 2006, a survey by the Genetics and Public Policy Center at Johns Hopkins University found that 42 per cent of 137 PGD clinics offered a gender-selection service.

The process involves fertilizing eggs in a lab. When the embryos are three days old, a single cell is removed and analyzed. If the cell has an abnormal chromosome count, the embryo is discarded. Healthy embryos are then implanted in the mother's womb.

While PGD has existed since the 1990s, the technology has now quietly progressed to the point that it can be used to create "designer babies" for hopeful parents who want to select their children's physical traits.

Dr. Jeff Steinberg, a pioneer of IVF in the 1970s who now runs the Los Angeles office of Fertility Institutes explains that his clinic started out by trying to screen out albinism and in the process, learned how to predict eye colour.

Dr. Mark Hughes, a molecular geneticist and the founder of the Genesis Genetics Institute in Detroit, where the world's first PGD was performed, says using the technology for gender selection is something his clinic "abhors."

"We developed this technology to help avoid serious inherited diseases that couples can carry," he told Canada AM.

"And hundreds of Canadians have used this technology because they know that they are at high genetic risk of cystic fibrosis or muscular dystrophy or hemophilia or whatever.

Now people are pretending that it can be used for trait selection and the truth is it can't."

Hughes notes that parents cannot select physical traits for which they don't carry the genes. So, for example, two black parents cannot ask for a blond, blue-eyed baby.

And other traits that parents might want their children to inherit, such as athleticism or beauty or intelligence, are not the result of a single gene, but multiple genes, some of which haven't even been identified.

"I would argue that if were looking to create a child through this technology with superior intelligence, you probably don't have those genes by default to give to your children," Hughes said, half-jokingly.

He also reminds that in order to take advantage of PGD, a couple would have to go through in vitro fertilization, which requires the injection of fertility drugs and uncomfortable and risky medical procedures.

"I don't care if you're a billionaire -- what kind of patient would go through the emotional and physical roller coaster of IVF so that they could have a child with freckles and a short nose?" Hughes wonders.

Steinberg told the Australian Associated Press recently that he believes that PGD technology has handed parents the ability to ensure their child is as healthy as possible and that the service his clinic now offers is just the natural extension of that.

"You can say eye colour and hair colour are not diseases, no they're not, and there is a cosmetic element to it, but we fix crooked noses all the time," Steinberg said.

"It's new, it's scary and it's not for everyone... but (people) shouldn't condemn it."

Comments are now closed for this story

John Black Ontario
said

Didn't the Germans attempt something along these lines in the Forties!.............


Future Mother
said

this is wrong on so many levels.. who are we to play G-d?


Scary times
said

just because you can, doesn't mean you should


Diane
said

Whenever man has tried to play God we run into trouble... wait for it its coming.


Not playing that role
said

Why are people being given the option to choose the gender of their children? Isn't this the same as the situation in China, where females are not valued and thrown on the street? What about when the child grows up? Do you tell him/her that "we chose to play G--, and decided to make you a boy/girl". Why aren't we focusing more on curing diseases instead of creating superhuman children? Society has moved forward in so many ways, but it makes us forgot what it means to be human. Do people actually say, when their first baby is born... "Oh no. It's a boy and I wanted a girl!"?


nc
said

We fix noses and people are still not happy.
I'm sure we will learn just as we did with cloning that all kinds of unforseen things can and will happen.
Good luck parents who wish to screen out life.


Ray Jr., Sudbury, ON
said

A new New-World approach to the human genome project. I'm sure it's only a matter of time before you get to browse through a catalog to pick out the "type" baby you want. Absurd. Unethical on so many levels. Unfortunately, there's obviously a large enough market for this in order for research of this nature to take place. That's really sad.


Cambob
said

Selecting the traits of embryos is as natural as doing math on a calculator, or using email to 'talk' to friends and family.

As for the Bible sect, "Let he who is without sin, cast the first On-Line Petition."


ME
said

How disgusting!!!

Does no ever think of the children, If Louise brown had a hard time coping with being a test tube baby how are these kids going to cope.

Mommy and daddy won't love me unless I'm perfect.

People in the states are dieing from lack of health care and the rich movie stars get designer babies. How's that for health care


Travis
said

Playing god? Whatever, we play god everyday, this is no different. Is invitro wrong? What about artificial hearts? If we didn't play god, imagine how many people would die everyday


Tyler I
said

As an addition to "Not playing that role"'s comment, China now has a less women than men to the tune of 40 million out-of-luck bachelors because of the cultural favoritism of men over women. I believe in the use of genetic research for purposes of health but to interfere in the balance of diversity is dangerous.


Expectant Mom in Ontario
said

Whatever happened to "you get what you get?" There's a 50% chance that you'll get a girl and a 50% chance you'll get a boy. My husband and I are expecting our second child and my only wish for this baby is that it's healthy. We have a daughter already and we're going to have another girl and we couldn't be more happy. Sure, we would have loved a little boy just as much but we're thankful that we're able to have another child at all.

I agree with "Not playing that role". These people should quit trying to play G-d and maybe focus on finding cures for diseases like cancer or diabetes, or AIDS to name a few. Parents should be happy with what they get because every child is a miracle, boy or girl.


Tono
said

People shouldn't condemn it?

I believe most people would disagree with that statement.

It is sad how irreverent and atheistic creation is viewed today.


sickened.
said

As someone who went through IVF to have a child, i understand the need for PGD - in the right circumstances, which is to look for genetic defects in embryos. Being female/male or born with brown/green/whatever eyes is not a genetic defect!

This is just the most disgusting thing i have ever heard of. The only thing sadder than a couple who would use PGD this way is the DOCTOR who would do the procedure.

A child is the most precious gift in the world, accept what you are given and get grateful.



Eric Gisin, BC
said

Don't blame eugenics on the Nazis, it was earlier supported by progessives: H. G. Wells, Woodrow Wilson, Theodore Roosevelt, Emile Zola, George Bernard Shaw, John Maynard Keynes, William Keith Kellogg, Margaret Sanger, Winston Churchill, and Sidney Webb.

Don't deny eugenics disappeared, it is widely used to prevent Down's Syndrome.


kevin in estevan sk
said

this is possibly the most disgusting thing i have heard coming out of medical science. thanx for removing nature from child birth. i am sure these "doctors" know much better than nature does.


Dave in Burnaby
said

I really don't see too much trouble with this. Screening out embryos for genetic disorders is probably helpful for humanity. It is no worse than giving a baby a vaccine.

Selecting hair colour is probably harmless. Gender could cause some problems if there ends up being more men than women a generation from now, or vice versa. But I don't even see that being bad enough to justify banning it the practice.


Andrew
said

This isn't a comment on the ethics (which I agree are slippery), but I just wanted to clarify something that many pointers seem to be missing in their haste to condemn. This is not 'genitically engineering the perfect baby' it's artificial selection - selecting from a pool of embryos. It's essentially the application of animal husbandry techniques to humans.


CalgarianBen
said

Lovely, now Americans can make there children the perfect accessory to match their wardrobes....



Sam C
said

Who are we to play God?

Shall we stop doing in-utero heart surgery and other corrective medical procedures on the unborn?

I'm not saying I agree with "designer children," but where do we draw the line? Do we just go back to letting nature take its course?


Yikes
said

Jurassic Park had a great quote and it pertains to this...it went something along the lines of, "you're scientists were so busy thinking about if they could, but they never stopped to think if they should."


Anne
said

I pity the poor children who grow up with parents who value certain traits over others. At a base level this displays a character flaw in prospective parents that is rather repulsive.


Renee
said

Besides this being wrong for sooo many reasons there is plenty of room for mistakes. There are people out there (including me) that can't choose a decent paint color even if their life depended on it. So now we are choosing hair color, eye color and maybe even things like skin color etc and you know, there may be a rash number of ugly kids born in the next few year thanks to this clinic!


angry medical student
said

That is medically unacceptable, what a slippery slope!!! What kind of doctor are you. I am pleased that we do not allow this kind of thing in Canada. Medicine should not be equivalent to ordering at Mcdonald's


Derek, BC
said

Drawing a parallel between choosing your baby's cosmetic appearance (eye, hair colour, etc.) and cosmetic surgery for things like crooked noses is wrong. If I get my nose fixed or some other cosmetic operation, I am choosing to do so; the choice is not being made by someone else as is the case with PGD. Perhaps tight regulations are required until society as a whole can agree on the ethical issues behind PGD, particularly when it comes to non-life threatening "alterations".


Paul in Brantford
said

This just underlines how we've lost our role as parents to children and become owners of a toy or pet.
Just disgusting....


B. Kelley, Ontario
said

I doubt that the liberal progressive censors will allow this letter to appear but, I can't help but wonder if the same people who are repulsed by the idea of "engineering" a child in the womb are as concerned about the idea of killing a child before birth. For right or wrong, society has accepted the notion that abortion is simply a woman's right to manage her own reproduction issues. That being the established norm, how can we argue with simply tweaking a child's physical characteristics? There's just no comparison in the gravity of the result.


CTY
said

Please stop using the term "playing God". Science is real, not imaginary.


island girl
said

Why does he say most parents want it to avoid genetic illness, and then turn around and call them 'designer babies'? Also, what does hair and eye colour have to do with anything detrimental to the fetus? Notice the emphasis is on physical traits? They don't bother with things like intelligence, or any psychological disorder that has organic roots that may be of benefit to mankind to avoid. Many of the world's geniuses have had physical challenges and the world would be poorer without them.


nervous
said

Wow, I can just see life insurance companies salivating to the fact that they will now screen humans for susceptible cancers since they weren't "genetically engineered" thus opening the door to, yes, unethical practices of discrimination in the future! sorry ma'am, we can't accept your son, he wasn't genetically engineered! We don't cover "rogues" born the good "ol" fashion way.

I agree that there is a benefit with this science, but that is the problem, the good always comes with the bad and that must be factored in.


mike
said

First of all, ethics are slippery, and context-related, and shift over time and place. People have differing perspectives on ethics, so calling something 'unethical' really does nothing to bolster an argument against this practice. It was once unethical to enjoy a drink (prohibition-era).

Secondly, I agree that it would be sad if there was a situation in which parents were unhappy with their child for not being 'perfect'. Such a reaction seems to suggest individuals that are not fit to be parents. This possibility would be a consequence of treating potential children as a commodity, which this prcoess of sleection seems to imply.

Thirdly, as for playing God, that argument doesn't apply for those who: a) don't believe in God, and b) believe in the use of medicine. Who can rightfully limit potential improvements to health? 'Playing God' is a criticism too easily thrown around without recognizing that using medicine in any capacity can also qualify as 'playing God'.

Finally, for the sake of avoiding genetic disease this technology is useful and beneficial and should be explored further.

In conclusion, as long as this is used for avoiding disease I support it. As for selecting genetic traits like hair and eye colour, it seems like it will happen anyhow, and I just hope that parents don't treat the child as less than something to be loved if they do not turn out as planned. I fear that such selection of traits treats children as a commodity available on the shelves of medical possibilities and this potentiality is what upsets me most.


Saddened
said

To Travis
"If we didn't play god, imagine how many people would die every day" BECAUSE we play god, imagine how many people die every day. We are flushing unwanted fetuses because of incorrect hair colour, we are 'mercy killing' people we don't think warrant a chance. Instead of using our knowledge to preserve life we are using it to destroy it.


Jeremy
said

So now we have egg storage, sperm donations, in lab fertilizaion, and screening before implantation! Doesn't this seem like we have all the ingredients to order the baby of your dreams?! Pick the mom, the dad, fertilize, screen, implant! With liberal thinking Obama we are on our way!! Sweet. (read SCARY)


Edmontonathan
said

Although it was only a matter of time before this emerged, the timing of it's arrival presents it as a band-aid solution for the woes the US is experiencing right now. With your world falling apart, why not be happy with a child of your design? I'm curious what kind of unknown changes this will introduce.


Allan (Vancouver)
said

I thought the idea was that those who don't know history are doomed to repeat it. Here we have people who are educated and I am assuming know history and are walking headlong back into it. What, do they think that they can handle this any better than it was handled in the past?This is stupid and arrogant.


Rick in NB
said

Didn't these guys ever watch The Outer Limits. These things never work in the end. There is always some kind of moral reason why.

PS: I'm pretty sure it's ok to type the word god in your posts. It's not a bad word.


r eddy in nb
said

this is only going to get more popular as time goes on and if it is banned some other country will do it so it can t be stopped life goes on.


jparchambeau
said

Yes, a world in which we limit the disease and suffering and as many as we can. I can certainly see how you all believe it to be so terrible and horrific. Attempt to look at the good side of something for a change.


maggie c in Sudbury
said

To Ray Jr. in Sudbury.

My now adult son is adopted, and accepted by everyone, warts and all.

I've posted comments in the Northern Life, under another name.

To those wanting a designer child, just be thankful you can have a child or children, never mind the design.

Just love them, accept them for who they are, not what they could or should be.

Hug yer kid every day, mine still emails me a hug a day.

Thank you for reading this.

GM
said

Question: Who are we to play God?

Answer: We are God's children, and we are just going into the family business


Chris
said

Cambob, you're argument is irrelevant and one should avoid twisting Biblical scripture to satisfy their argument of the time. According to your line of thought, we shouldn't try murder's or rapists either because we're all guilty of sin, do you believe this ?

This is extremely unethical. We don't understand the ramifications that a child's life has on us. If that child is to be born with a diease or male/female with brown or black hair who cares ? We're not giving this person a chance to add value and all the other gifts they bring to to this world. We're essentially using technology to objectify human life and build the "perfect" child much like the perfect machine.

How sad a day when we equate life to objects and machines. God help us all, for we know not what we do.

Chris


Gail (Hamilton)
said

We are giving in to the "tradition of men, after the rudiments of the world". An embryo is an UNBORN CHILD. Designer children are merely commodities to be made in the image we want. Science used to defeat disease is a great cause. Science used to create children is another kick at God through the ignorance of mankind. Our future will forever be changed because we have failed to realize that the Spirtual War and the Cultural War were one and the same.


merna
said

RIGHT ON!! can they finally get rid of that "crying gene?"


Ready In Ontario
said

I wonder if anyone else has thought this through.
What if this is the next step in terms of human evolution?
What if we have a child that is modified or born in this way, that would not have been born any other way due to a infertal Mother or Father, one that grows up to cures cancer, aids, or maybe just makes this a bit better world than it is right now?
Anything is possible. Who are we to judge the doctors or the people who opt for this treatment. As for me I would still like to practice the old way of making baby's with the 50:50 odds unless I can't anymore.

I still feel that we should give everyone the chance to make their own mind up.


ashamed to live in canada
said

what is our country coming to?!? ...this is very wrong


Dani
said

This is horrid, I do not see how any good can come of it. At the very least, it is going to encourage sociological stereotypes and the image of the "perfect person". At the worst...well, I hate to imagine.


Ben, Edmonton
said

Hey, if you think it's wrong, don't do it. Personally, I think it's terrible, but I know a lot of dumb-enough people that would go through with something like this. Darwin must be rolling over in his grave somewhere.


Crazy Jim
said

All hail Khan!


Cam
said

When we sit in judgement of our fellow human beings, and decide it is immoral to "design" children, are we not also playing God?



Socialism is killing us
said

Vain, selfish, hypocritical idiots with the me, me, me attitude. This is a failure of a liberal led society where freedoms and rights are given, not earned. Just disgusting.


Carrie
said

I think that this kind of behaviour most certainly should be "condemned". When we talk about eliminating birth "defects" and "disorders" we are failing to recognize that these are actual human beings that we are referring to. My youngest sister has Down's Syndrome, one of the many "defects" that these doctors are trying to get rid of. She is the greatest blessing to ever happen to our family; she brings joy and a sense of innocence that you cannot find in humans who aren't "defective". I wish that people would recognize this, before we screw ourselves over completely from imagining that we can play God.


Meredith
said

Has anyone seen Gattaca? Thats where we will soon be headed... the genetically superior versus the genetically inferior


Prynce
said

Who the heck do you think you people are to tell me what I can and can't do with my future child, My future child has a right to a healthy future, just like you have a right to organ transplants, and a right to not have 2nd hand smoke enter your lives, and a right to use gene therapy to cure illnesses. And for those uneducated..... it's not a test tube baby, the embryo is designed outside the womb with motehrs and fathers sperm and egg and implanted through in vitro fertilization. Only GOD and the Government has the right to tell me what I can and can't do with my future child. And If I don't like the laws, I can have them changed if the masses agree or. I can move, and the same to you too. SO shut up and mind your own personal life and keep your nose out of ours.

P.S. Some people are so bored that they have to stick their noses in others business, just remember one day someone will make your life miserable by sticking their nose in your personal business. Such a shame that people push freedom of speech to such horrible uses.


Winter
said

This is interesting...there are a lot of people condemning it. I don't see a problem. I think that it should just be accepted. I don't have kids and plan on having one in the mid to near future, hopefully naturally. But if I was not able to produce a child of my own and needed IVF, I would gladly like to choose the look of my child. In that sense, I am shallow. But if things screwed up and the kid ended up with red hair, I would love him/her all the same. I think giving people the preference is kinda cool. And the ethics...well, we allowed worse things to happen in Gitmo Bay and other places all over the world, and you are really threatened by this? I would be ashamed. Open your eyes and see the real ethical dilemmas we should be dealing with..


frank B.
said

I think alot of people are confused about what this article is about. They are just picking from the selection of fertilized embryos. Rather then randomly choosing one they look at the genetic traits and pick the one that has the traits they want. There was always a chance before that it could have been the one born at random. The problem is it opens doors for research and procedures that should never be done.


John from TO
said

Yup. Just goes to show what you can do if you have the money. Bad enough theres yuppies out there that spend their way into debt to keep up with the Jonses on everything from cars, to jewlery to trips and cloths. Now theyll be comparing babies, and how much work they had done before their child was born. This will come back to haunt them. When you play god, something usually goes wrong at some point.


marie in Montreal
said

What exactly is pre-implantation genetic diagnosis? Sounds to me like the term selective reduction. Another politically correct term for throwing out a human being. Based on what? On hair and eye colour...just how low can we go?


Amanda From Kingston,ON
said

I think having a child the normal way(old fashion way)is great wether people don't care if it's a boy or girl, but the most important thing every parent wants is a healthy child.
But has anyone posting these comments ever thought about the millions of people who can't have a child, the women/men who have been trying for 5-10 years maybe longer to get pregnet. Or how about the gay and lesbian community who want to start their own family and need a little help, yes curing genetic diseases are great but what if you have to choose a donor male and female to get pregnet isn't it the best feeling in the world to know the baby looks like you or your partner? to know he/she has your big blue eyes or your curley brown hair.
Or maybe we should all just be angry at each other, with the amout of toxic pollution that we are inhailing and injesting no wonder so many people are having fertilization problems. We are just power driven money hungry world, who ever has the biggest and best of everything wins.
Well not all of us are that lucky!!!


Wish I Was A Designer Baby!
said

There's absolutely nothing wrong with this. It's infinitely preferable to aborting diseased fetuses, which is being done now. I have Bipolar Disorder and I wish to God my parents could have had it designed out of me in the sixties when I was born.

We may have a deluge of couples from Asian countries selecting boy babies, but they are shooting themselves in the foot; after all, most people marry within their ethnic group, and it would mean fewer eligible girls for the sons of those couples. As for the designer baby aspect, we already know that the top qualities that parents will select are beauty, brains and compassion. Bring on the future!


»Biinkz«
said

This is CRAZY!!! What ever happened to the excitement of wondering what your going to have? What is there to look forward to if you have a blueprint of what your child would become. This is so sad that our society has become so shallow and wants everything to be perfect. You don`t know what purpose the child will serve in this world, by deciding that on your own is messing with the way the mankind is made. We haven`t turned out too bad so why do you feel it`s okay for you to create your own perfect child. Let things be as it should and continue to discuss whether it will have the father`s nose or the mother`s hand, or maybe it will take afther niether parents and take after grandparents. Who knows but it`s wonderful once the child arrive to see what you have created naturally.


Christine, Surrey
said

Every time someone consciously chooses one embryo over another they make a statement that the qualities of embryo A are better than those of embryo B, i.e.: that one type of life is more valuable than another. Whether intentionally or not, when we select out embryos with Down's, we say as a society that a life with Down's syndrome is not worth living, and neither is one with Parkinson's, autism, two X chromosomes, green eyes, or whatever (or that these children are simply too much trouble for the parents to raise). What does this say about people who are born with these conditions/qualities? What does this say about children in general, as commodities and consumer goods, and as the paid-in-full property of their parents, rather than autonomous human beings?


saddened
said

I am glad I am as old as I am. I will be dead before this goes mainstream. I do not want to be part of a world with all the flavour taken out of it. The popular view of 'beauty' is very limited and if they can program thought processes too, eventually, the world will be full of tall skinny drones and I am glad I won't be here.


Christina
said

As a woman, who was born with a disability (Spina Bifida) I'd just like to say I'm absolutely disgusted. For those people who can't "bear" to have children with complications or want children with certain characteristics - that's ridiculous! I sincerely hope that the parents realize what they're doing is morally and ethically WRONG.


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