25 Years of Oprah

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  Over the past 25 years Oprah has grown from being just another talk show host to providing a dominant cultural platform to showcase stars and regular folk alike. Click through and view some of the key moments that captured audiences for over two decades.
  Harpo Productions

  

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  Comedian Bob Hope laughs with television talk show host Oprah Winfrey during the taping of the Oprah Winfrey Show in Chicago, May 22, 1990.
  AP Photo/Charles Bennett

  

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  Oprah Winfrey sits atop a Pontiac G6 outside her Chicago studios, surrounded by some of the 276 people from her audience who each received one of the new cars at the start of the show to celebrate the premiere of her 19th season.
  Harpo Productions, Inc./George Burns

  

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  Oprah Winfrey with former U.S. vice presidential candidate Sarah Palin and her daughters, Willow, right, and Piper, left, during the taping of 'The Oprah Winfrey Show' in Chicago, Wednesday, Nov. 11, 2009.
  Harpo Productions, Inc./George Burns

  

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  Oprah Winfrey poses with former world champion boxers Mike Tyson, right, and Evander Holyfield on a live episode of 'The Oprah Winfrey Show,' Friday, Oct. 16, 2009, in Chicago.
  Harpo Productions, Inc./George Burns

  

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  Oprah Winfrey appears with the Black Eyed Peas, Tuesday, Sept. 8, 2009, while taping an episode of 'The Oprah Winfrey Show' on a three-block stretch of Chicago's Michigan Avenue near the Chicago River, to celebrate the 24th season of her show.
  AP Photo/Kiichiro Sato

  

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  Oprah Winfrey and Whitney Houston are seen during an interview at the Town Hall in New York, Aug. 31, 2009/ Houston, who's new album 'I Look To You' was released on Aug. 31, was interviewed by Winfrey for a two-part season premiere of The Oprah Winfrey Show.
  Harpo Productions, Inc./George Burns

  

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  Gerry and Kate McCann talk with Oprah Winfrey about the search for their missing daughter Madeleine during a taping of 'The Oprah Winfrey Show,' April 24, 2009.
  Harpo Productions, Inc./George Burns

  

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  Oprah Winfrey shows off her new figure in Chicago after she lost 67 pounds following a liquid diet and exercise, Nov. 15, 1988.
  AP Photo/Charles Bennett

  

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  Barbara Walters holds the hand of Oprah Winfrey during an interview for 'The Oprah Winfrey Show,' in April 2008. After three decades of keeping mum, Barbara Walters now says she had a past affair with married U.S. Senator Edward Brooke.
  Harpo Productions, Inc./George Burns

  

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  Michael Jackson gives his first TV interview in more than a decade and discusses his oddly changing looks on a highly rated live prime-time special, 1993.
  Harpo Productions, Inc.

  

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  In 2005, Tom Cruise's offered a madcap couch-jumping demonstration of affection for Katie Holmes that would become one of the most talked about entertainment moments of the year.
  Harpo Productions, Inc./George Burns

  

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  Oprah Winfrey gestures during her live interview with James Frey, author of 'A Million Little Pieces,' Jan. 26, 2006. Winfrey challenged Frey over his disputed memoir during the telecast, asking him to explain why he 'felt the need to lie.' Frey's story of substance abuse and recovery became one of the best-selling books of 2005 after Winfrey named it to her book club.
  Harpo Productions, Inc./George Burns

  

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  Barack Obama, his wife Michelle and Oprah Winfrey wave to the crowd at a rally in Manchester, N.H. in 2007. A University of Maryland study finds her endorsement may have netted him about 1 million votes in the Democratic primary.
  AP Photo/Elise Amendola

  

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  Oprah Winfrey puts her feet up as she relaxes in her studio office following a morning broadcast in Chicago, Dec. 18, 1985.
  AP Photo/Charlie Knoblock

  

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  Ellen DeGeneres, playing character Ellen Morgan, discusses her fears about coming out as a lesbian with her therapist, played by Oprah Winfrey, during a taping of the sitcom 'Ellen,' on March 14, 1997.
  Touchstone Television/Mike Ansell

  

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